CMS-121 Powder CAS.1353224-53-9 99% Min
English name: CMS-121
CAS number: 1353224-53-9
Molecular formula: C₂₀H₁₉NO₃
Molecular weight: 321.37g/mol
Capacity: 500kgs per month
Source: synthetic
Purity (HPLC) >99.0%
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat for 2 years
Description
Xi’an Yinherb Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of cms-121 powder cas.1353224-53-9 99% min in China, also supports customized service. Welcome to buy bulk cms-121 powder cas.1353224-53-9 99% min for sale here from our factory. Quality products and reasonable price are available.
Leading Research lab on Nutritional Supplements in China
Yinherb Lab is a professional research Lab in china, have focused on Nutritional Supplements, Nootropics and Peptide raw materials researching and producing in this market for over 10 years with stable quality and great reputations, we can supply every batch test, including COA, HPLC and NMR. I believe that we must work well in future.
Yinherb Lab High Quality CMS-121 Powder CAS.1353224-53-9 99% Min
| Product Name | CMS-121 Powder |
| Chemical Full Name | 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol |
| CAS Number | 1353224-53-9 |
| Molecular Formula | C₂₀H₁₉NO₃ |
| Molecular Weight | 321.37 |
| Synonyms | 4-[4-(Cyclopentyloxy)-2-quinolyl]-1,2-benzenediol; ACC1 |
| Appearance | Pale yellow to white crystalline powder |
| Purity (HPLC) | ≥ 98.0% |
| Melting Point | 168–172℃ (decomposition point may occur above 180℃) |
| Solubility | Soluble in DMSO (≥ 20 mg/mL), slightly soluble in ethanol and methanol, insoluble in water |
| Partition Coefficient (Log P) | ~4.2 (estimated, octanol/water system) |
| pH (1% Solution in DMSO) | 6.0–7.5 |
| Stability | Stable under recommended storage conditions; sensitive to light and high temperature |
What is CMS-121 Powder?
CMS‑121 Powder (CAS 1353224‑53‑9, ≥99% HPLC) is a potent, orally active ACC1 inhibitor with multi‑modal activity: neuroprotective, antioxidant, anti‑inflammatory, and renoprotective. It protects neurons at nM concentrations, improves cognition in aging models, and reduces renal inflammation. Ideal for neuroscience, metabolic, and anti‑aging R&D, its high purity and stability ensure reliable in vitro/in vivo results.
High purity ≥98%–99% (HPLC/LC‑MS) with strict impurity control
Orally bioavailable, stable crystalline form
Potent nM‑range activity in cellular assays
Multi‑target: neuroprotective, antioxidant, anti‑inflammatory, renoprotective
Well‑characterized in vitro & in vivo models
CMS-121 PowderMechanism of Action
1. Enzyme Target Inhibition
Inhibits acetyl‑CoA carboxylase 1 (ACC1) and fatty acid synthase (FASN)
Reduces lipid synthesis and peroxidation
Potently suppresses oxidative stress‑induced cell death and ferroptosis
2. Antioxidant and Anti‑inflammatory Effects
Scavenges reactive oxygen species (ROS) and reduces lipid peroxides
Inhibits the NF‑κB pathway and pro‑inflammatory cytokines (TNF‑α, IL‑6, etc.)
Alleviates oxidative stress and inflammation
3. Neuroprotective Pathways
Upregulates Akt phosphorylation, protecting neurons against ischemia‑reperfusion injury
Maintains brain mitochondrial gene expression and acetyl‑CoA levels
Improves cognition and slows neuronal degeneration
4. Other Protective Effects
Protects renal endothelial cells and reduces kidney injury
Attenuates age‑related hearing loss by inhibiting oxidative stress and ferroptosis
CMS-121 Powder Key Application Areas (Research Progress)
1. Neurodegenerative Diseases
In Alzheimer's disease mouse models: reduces lipid peroxidation, improves cognition and memory, and slows neuronal degeneration
Shows potential neuroprotection in Parkinson's disease models
2. Ischemic Brain Injury
In oxygen‑glucose deprivation/reoxygenation (OGD/R) neurons and mouse ischemia‑reperfusion models:
Reduces neurological deficit scores
Decreases infarct volume
Attenuates neuronal damage
3. Age‑Related Hearing Loss
In SAMP8 mice: inhibits ferroptosis and oxidative stress, delaying hearing decline
4. Kidney Protection
Reduces renal ischemia‑reperfusion injury
Decreases markers of inflammation and oxidative damage
5. Metabolic and Aging‑Related Diseases
Improves lipid metabolism disorders
Delays age‑related decline in cellular function
CMS-121 Powder Comparison with Related Compounds
| Compound | Core Targets | Advantages | Primary Applications |
|---|---|---|---|
| CMS‑121 | ACC1/FASN | Potent ferroptosis inhibition; strong neuroprotection | Neurodegenerative diseases, ischemic brain injury |
| Fisetin | Multiple antioxidant pathways | Natural source; high safety | Anti‑aging, metabolic regulation |
| 1‑MNA | Anti‑inflammatory pathways | Vitamin B3 metabolite; strong anti‑inflammatory effects | Cardiovascular, skin, neuroprotection |
| Urolithin A | Mitophagy | Activates PINK1/Parkin; strong anti‑aging effects | Anti‑aging, sports nutrition |
CMS‑121 is more potent than natural fisetin in ferroptosis inhibition and neuroprotection.
CMS-121 Powder Test From Yinherb Lab
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Yinherb Lab founded in 2009, has been deeply committed to the biotechnology field for over a decade. Today, it has established a professional development framework integrating "R&D + production" as an integrated system. And always adhered to the core business philosophy of "Quality First, Service Second, Price Third".
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