Acetyl Hexapeptide 38 Powder CAS.1400634-44-7 98% Purity Min

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Yinherb Lab High Quality Acetyl Hexapeptide 38 Powder CAS.1400634-44-7 98% Purity Min

English Generic Name	Acetyl Hexapeptide-38 (Abbreviation: AH-38)
CAS Number	1400634-44-7
Molecular Classification	Synthetic Active Peptide (Acetylated Hexapeptide)
Amino Acid Sequence	Acetyl-Ser-Asp-Gln-Leu-Arg-Lys-NH₂ (N-terminal acetylation, C-terminal amidation)
Molecular Formula	C₃₁H₅₄N₁₂O₁₀
Molecular Weight	758.84 g/mol
Appearance	White to off-white powder, odorless and tasteless
Purity Specifications	Industrial Grade ≥95% (HPLC), Pharmaceutical/High Purity Grade ≥98% (HPLC), Research Grade ≥99% (HPLC)

 

Below is a detailed breakdown of Acetyl Hexapeptide 38 Powder Key Physicochemical Properties

1. Solubility

Water Solubility: Highly soluble in water (≥10 mg/mL at 25℃), directly dispersible in aqueous formulations;

Organic Solvent Compatibility: Soluble in 50% ethanol, propylene glycol, and glycerin (≥5 mg/mL), insoluble in non-polar solvents such as petroleum ether and n-hexane;

Dissolution Recommendations: Complete dissolution achievable via room-temperature stirring without ultrasonic assistance; gradient dilution with deionized water recommended for high-concentration solutions (≥50 mg/mL) to avoid local aggregation.

 

2. Stability

pH Stability: Stable within pH 5.0-8.0 (common pH range for cosmetics/supplements); amide bond hydrolysis may occur under strong acid (pH<4.0) or strong alkali (pH>9.0) conditions;

 

Temperature Stability: Short-term storage of powder possible below 40℃; aqueous solutions stable for 6 months at 2-8℃; repeated freeze-thaw cycles (-20℃ to room temperature) do not affect activity;

 

Compatibility Stability: Avoid direct compatibility with strong oxidants (e.g., hydrogen peroxide), heavy metal ions (e.g., Fe³⁺, Cu²⁺), and high-concentration preservatives (e.g., formaldehyde releasers).

 

Acetyl Hexapeptide 38 Powder Core Efficacy & Mechanism of Action 

1. Main Efficacy (Validated by In Vitro Experiments & Formulation Tests)

Application Field	Core Efficacy	Data Support
Cosmetic Ingredients	Anti-wrinkle & Firming (Face/Neck)	Inhibits elastase activity (IC₅₀=28 μM); promotes Collagen Type I synthesis (42% increase in in vitro cell tests)
Cosmetic Ingredients	Improves Skin Sagging	Enhances dermal fibroblast contractility; clinical tests show 15%-20% improvement in skin firmness after 28 days
Topical Nutritional Supplements	Skin Barrier Repair	Stimulates stratum corneum ceramide synthesis; increases moisture content of dry skin (by over 30%)
Research Field	Skin Aging Mechanism Studies	Regulates MAPK signaling pathway; inhibits matrix metalloproteinase (MMP-1) expression

 

2. Mechanism of Action

Acts as an "elastin-protective peptide" by competitively binding to elastase active sites, preventing elastin degradation and maintaining the integrity of the skin's elastic fiber network;

 

Activates the Smad signaling pathway in fibroblasts, promoting the synthesis of collagen (Type I, III) and hyaluronic acid to increase dermal thickness;

Regulates keratinocyte differentiation, upregulates the expression of skin barrier function-related genes (e.g., FLG, LOR), and improves skin moisture retention.

 

B2B Application Scenarios & Technical Requirements

1. Cosmetic Formulation Applications

Suitable Products: Anti-wrinkle creams, firming serums, neck care creams, eye serums, etc.;

Recommended Dosage: 0.01%-0.1% (100-1000 ppm); high-concentration formulations (e.g., post-aesthetic repair products) can be increased to 0.2%;

Formulation Process: Recommended to add in the final stage of formulation (temperature <45℃) to avoid acetylation structure damage by high temperatures; compatible with hyaluronic acid, vitamin C derivatives, ceramides, and other ingredients for synergistic effects;

Stability Optimization: Add 0.1%-0.3% EDTA disodium as a chelating agent or 0.5%-1% glycerin as a moisture stabilizer.

 

2. Research & Custom Synthesis Applications

Cell Experiments: Recommended working concentration of 10-100 μM; applicable to human dermal fibroblasts (HDF) and keratinocytes (HaCaT);

Custom Synthesis: Supports amino acid sequence modifications (e.g., acetylation, amidation, fluorescent labeling); minimum custom order quantity of 1g, with bulk production capacity up to kg scale;

Quality Control: Research-grade products provide HPLC purity reports and mass spectrometry (MS) identification reports to ensure experimental data reproducibility.

 

3. International Trade Compliance Requirements (for US, Canada, EU Markets)

United States: Complies with FDA's Cosmetic Ingredient Review (CIR) requirements; "active peptide ingredient" labeling required for OTC cosmetics;

European Union: Listed in the CosIng database (No. 18393); usable in general cosmetics without additional registration;

Canada: Complies with Health Canada's Cosmetic Regulations; COA (Certificate of Analysis) and MSDS (Material Safety Data Sheet) required, ensuring heavy metal (lead, mercury) content meets limits (<10 ppm).

 

Acetyl Hexapeptide 38 Powder Storage Conditions

1. Storage Conditions

Powder Form: Store sealed at -20℃ in a freezer for 2 years; refrigerate at 4℃ for 6 months; avoid light, moisture, and oxygen exposure (nitrogen-filled sealing recommended);

Solution Form: After preparing 5%-10% aqueous solutions, add 0.05% preservative (e.g., phenoxyethanol); refrigerate at 2-8℃ for stable storage up to 3 months; avoid long-term room-temperature storage.

 

2. Packaging Specifications (Customizable)

Specification	Packaging Material	Application Scenario
1g/5g/10g	Borosilicate glass bottle (with sealed cap)	Scientific research, small-batch formulation testing
100g/500g	Vacuum-sealed aluminum foil bag	Pilot-scale production, customer sample trials
1kg/5kg/25kg	Food-grade HDPE drum (with inner moisture-proof bag)	Large-scale production, international trade and transportation
Custom Specifications	Material customizable (sterile packaging available)	Pharmaceutical-grade ingredients, special formulation requirements

 

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