WAY 316606 Powder CAS.915759-45-4 99% Min
Product name: WAY 316606 Powder
CAS No.915759-45-4
Molecular formula: C₂₁H₂₄O₂
Molecular weight: 308.42
Purity: 99.0%
Capacity: 100kgs per month
Source: synthetic
Purity (HPLC) >98.0%
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat for 2 years
Description
Xi’an Yinherb Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of way 316606 powder cas.915759-45-4 99% min in China, also supports customized service. Welcome to buy bulk way 316606 powder cas.915759-45-4 99% min for sale here from our factory. Quality products and reasonable price are available.
Leading Research lab on Nootropics & peptide in China
Yinherb Lab is a professional research Lab in china, have focused on Nutritional Supplements, Nootropics and Peptide raw materials researching and producing in this market for over 10 years with stable quality and great reputations, we can supply every batch test, including COA, HPLC and NMR. I believe that we must work well in future.
Yinherb Lab High Quality WAY 316606 Powder CAS.915759-45-4 99% Min
Product name: WAY 316606
Chemical Name: 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethenyl]benzoic acid
CAS Number: 446292-06-6
Molecular Formula: C₂₁H₂₄O₂
Molecular Weight: ~308.42
Drug Class: Selective retinoic acid receptor gamma (RARγ) agonist
Purity Standard: ≥98% (pharmaceutical R&D grade; verified by HPLC/NMR)
Purity: ≥98.0% (HPLC assay)
Single Impurity: ≤1.0% (individual impurity)
Total Impurities: ≤2.0%
Loss on Drying: ≤0.5% (105°C, 2 hours)
Residue on Ignition: ≤0.1%
Solvent Residues: Complies with ICH Q3C (for R&D use)
Appearance: White to off-white crystalline powder, odorless
Solubility: Insoluble in water; soluble in organic solvents (DMSO: ≥100 mg/mL, ethanol: 20–30 mg/mL, acetone: 15–25 mg/mL)
Melting Point: Approximately 228–232°C (DSC analysis)
Stability: Stable under cool, dry, dark conditions; sensitive to UV light, strong acids, and oxidizing agents
What is WAY 316606 Powder?
WAY 316606 Powder (CAS 915759-45-4, ≥98% HPLC) is a potent, selective sFRP‑1 inhibitor that activates Wnt/β‑catenin signaling. It is widely used in anti‑hair loss research, osteoporosis studies, and high‑end scalp care cosmetics. With dual efficacy in stimulating hair follicle growth and promoting bone formation, it serves as a critical tool compound for Wnt pathway research and a promising lead for hair growth and anti‑osteoporosis drug development. High purity, stable quality, and good solubility make it ideal for research, cosmetic formulation, and pharmaceutical R&D.
Core Features
High‑purity, selective sFRP‑1 inhibitor with potent Wnt signaling activation.
Demonstrates dual efficacy in stimulating hair follicle growth and promoting bone formation.
High selectivity for sFRP‑1 (≥10× over sFRP‑2) minimizes off‑target effects.
Good solubility in organic solvents enables easy formulation for research, cosmetics, and preclinical studies.
Strict quality control ensures batch‑to‑batch consistency and reliable experimental reproducibility.
WAY 316606 Powder Mechanism of Action
WAY-316606's hair-regrowth effect is rooted in selective RARγ activation-a non-hormonal pathway critical for hair follicle cycling and regeneration:
RARγ Targeting: Binds specifically to retinoic acid receptor gamma (RARγ), expressed abundantly in hair follicle stem cells and dermal papilla cells.
Initiates Anagen Phase: Activates downstream genes (e.g., Shh, Wnt) that trigger the transition from telogen (resting) to anagen (growth) phase, reducing hair shedding.
Enhances Follicle Regeneration: Stimulates proliferation of hair follicle stem cells and dermal papilla cells, reversing miniaturization of androgenetic alopecia-affected follicles.
Synergistic with Minoxidil: Preclinical data shows it amplifies minoxidil's efficacy by improving follicle responsiveness to growth signals (no direct DHT blocking).
WAY 316606 Powder Applications & Formulation Guidelines
Primary Use
Hair Loss R&D: Core raw material for preclinical/clinical studies on androgenetic alopecia (male/female) and alopecia areata.
Potential Formulations: Topical serums, lotions, or microneedle patches (systemic absorption is minimal for RARγ agonists).
Formulation Compatibility
Optimal Concentration: 0.01–0.1% (R&D formulations; higher concentrations may cause scalp irritation).
Compatible Excipients: Ethanol, propylene glycol, DMSO (small amounts as penetration enhancers), HPMC (thickener), panthenol (soothing agent).
Incompatible Substances: Strong acids/bases, UV-sensitive ingredients, high-moisture formulations (without preservatives).
Comparison Table: Similar Hair Loss Treatment Ingredients
| Comparison Dimension | WAY-316606 Powder | Minoxidil | Finasteride | Clascoterone/Fluridil | SM04554 |
|---|---|---|---|---|---|
| Target Pathway | Selective RARγ activation (retinoic acid receptor gamma) | Potassium channel opening + angiogenesis | 5α-reductase inhibition (reduces DHT production) | Androgen receptor antagonism (blocks DHT-follicle binding) | Wnt pathway activation (GSK-3β inhibition) |
| Mechanism Focus | Follicle stem cell proliferation + anagen phase initiation | Extends anagen phase + improves follicle blood supply | Halts DHT-mediated follicle miniaturization (hormonal blocking) | Halts DHT-mediated follicle miniaturization (local receptor blocking) | Reverses follicle miniaturization + stem cell differentiation |
| Hormonal Interaction | None (non-hormonal; no DHT/testosterone impact) | None (non-hormonal) | Strong hormonal modification (reduces systemic DHT) | None (local anti-androgen; no systemic hormone change) | None (non-hormonal) |
| Key Advantage | Synergistic with minoxidil (amplifies efficacy); targets stem cell regeneration | Gender-neutral; proven regrowth; widely available | High potency for male pattern baldness | Safe for men/women; no systemic side effects | Stimulates new follicle formation (beyond just preserving existing ones) |
| Limitations | Early R&D stage (no FDA approval); mild irritation at high concentrations | Requires daily application; no effect on severe baldness | Male-only use; sexual side effects; teratogenic risk for women | Mild regrowth efficacy; slower onset than minoxidil | Development suspended; limited commercial availability |
| Formulation Focus | Topical (serums, microneedle patches); low concentration (0.01–0.1%) | Topical (solutions/foams); 2–5% concentrations | Oral (tablets); topical in development | Topical (serums/lotions); 1–2% concentrations | Topical (serums); 0.5–1% concentrations |
Related products
Specized in Fevipiprant, Minoxidil, Fluridil, SM04554, Clascoterone CB-03-01, β-estradiol, WAY316606, etc.
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Yinherb Lab founded in 2009, has been deeply committed to the biotechnology field for over a decade. Today, it has established a professional development framework integrating "R&D + production" as an integrated system. And always adhered to the core business philosophy of "Quality First, Service Second, Price Third".
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