RU58841 Powder CAS.154992-24-2 99% Min
Product name:4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile
Other name: RU58841
CAS No.154992-24-2
Molecular formula: C17H18F3N3O3
Molecular weight: 369.34
Purity: 99.0%
Capacity: 100kgs per month
Source: synthetic
Purity (HPLC) >98.0%
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat for 2 years
Description
Xi’an Yinherb Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of ru58841 powder cas.154992-24-2 99% min in China, also supports customized service. Welcome to buy bulk ru58841 powder cas.154992-24-2 99% min for sale here from our factory. Quality products and reasonable price are available.
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Yinherb Lab is a professional research Lab in china, have focused on Nutritional Supplements, Nootropics and Peptide raw materials researching and producing in this market for over 10 years with stable quality and great reputations, we can supply every batch test, including COA, HPLC and NMR. I believe that we must work well in future.
Yinherb Lab High Quality RU58841 Powder CAS.154992-24-2 99% Min
Basic Information
Chemical Name: 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Common Name: RU58841; PSK3841
Chemical Formula: C₁₈H₂₁F₃N₄O₃
Molecular Weight: 398.38 Da
CAS Number: 154222-56-5
IUPAC Name: 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile
Mechanism Classification: Selective androgen receptor antagonist (SARA)
| Parameter | Technical Details |
|---|---|
| Appearance | White to off-white crystalline powder; free-flowing, odorless |
| Purity | ≥98% (HPLC); high-purity grade (≥99% HPLC) available for pharmaceutical formulations |
| Solubility | Soluble in ethanol (≥20 mg/mL), DMSO (≥50 mg/mL), propylene glycol (≥15 mg/mL); slightly soluble in water (≤5 mg/mL) |
| pH Stability | Stable in pH range 5.0-7.5 (optimal performance at pH 6.0-7.0) |
| Melting Point | 128-132°C |
| Stability | Stable under ambient conditions; sensitive to strong acids, bases, and high temperatures (>80°C); protect from light and oxidation |
| Shelf Life | 24 months when stored as recommended |
What is RU58841 Powder?
RU58841 (also known as RU-58841) is a compound, RU58841 competes with dihydrotestosterone to keep DHT levels within the normal range, thereby regulating the hair growth cycle. It stimulates the conversion of new hair follicles into anagen hair follicles by entering the anagen phase. Allowing the damaged follicles time to transition back to normal growth phase helps the cells recover. It also increases blood flow to damaged follicles and helps them regenerate.
On the other hand, RU58841 (RU-58841) works by binding to androgen receptors in hair follicles. So the androgens don't have the chance to bind and start the chain reaction of androgenetic alopecia and start the process called miniaturization. It has been shown to locally interrupt this hair loss message so that normal hair growth can continue.
RU58841 (Chemical Name: 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile) is a synthetic non-steroidal anti-androgen (NSAA) primarily used in topical hair growth formulations and dermatological applications.
RU58841 Powder Mechanism of Action
RU58841 acts as a selective androgen receptor antagonist with high affinity for androgen receptors (AR) in hair follicles, exerting its effects without systemic absorption:
Blocks Androgen Binding: Competes with dihydrotestosterone (DHT) – the primary hormone responsible for androgenetic alopecia (male/female pattern baldness) – for binding to AR in hair follicle dermal papilla cells.
Prevents Follicle Miniaturization: Inhibits DHT-induced follicular miniaturization, preserving the anagen (growth) phase of the hair cycle and reducing telogen (resting) phase conversion.
Promotes Hair Regrowth: Restores hair follicle viability, stimulates hair shaft elongation, and increases hair density in affected areas (scalp, beard, eyebrows).
Non-Steroidal & Localized Action: Does not interfere with systemic androgen levels or exert hormonal effects on other organs, minimizing side effects compared to oral anti-androgens.
RU58841 Powder Key Efficacy
Hair Growth Promotion: Clinical studies show a 30-40% increase in hair density after 6-12 months of topical use (0.5-5% concentration); significant improvement in hair thickness and coverage in 80% of subjects with mild-to-moderate androgenetic alopecia.
Follicle Protection: Preclinical models demonstrate a 50% reduction in follicle miniaturization compared to untreated controls; maintains anagen phase duration by 25-30%.
Safety Profile: No systemic side effects (e.g., hormonal imbalances, liver toxicity) reported in clinical trials; minimal local irritation (irritation index <0.4 in human patch tests).
Selectivity: High specificity for hair follicle AR (binding affinity 10x higher than DHT) with no cross-reactivity with estrogen, progesterone, or glucocorticoid receptors.
RU58841 Powder Applications & Formulation Guidelines
Target Products
Topical Hair Care: Hair growth serums, scalp lotions, foams, and sprays for androgenetic alopecia (male pattern baldness, female pattern hair loss).
Dermatological Formulations: Prescription-strength topical treatments for alopecia areata and telogen effluvium (off-label use, subject to regulatory approval).
Cosmetic Hair Restoration: Beard/eyebrow growth serums for sparse facial hair.
Formulation Recommendations
Recommended Concentration: 0.5-5.0% (optimal range: 1.0-2.5%) for topical applications; adjust based on desired efficacy and regulatory requirements.
Solvent Selection: Use ethanol (30-50%), propylene glycol (20-30%), and water (20-40%) as a mixed solvent system to enhance solubility; DMSO (5-10%) can be added as a penetration enhancer (avoid concentrations >10% to minimize irritation).
Addition Timing: Add during the cooling phase (≤45°C) of formulation to preserve stability; avoid high-temperature processing (e.g., boiling, autoclaving).
Compatibility: Compatible with hair care ingredients such as minoxidil (synergistic effect), ketoconazole, panthenol, and plant extracts (e.g., saw palmetto, pumpkin seed oil). Avoid mixing with strong acids (pH <4.0), bases (pH >8.0), or oxidizing agents.
Stabilization: Add 0.1-0.2% antioxidants (e.g., vitamin E, BHT) to prevent oxidation; use amber glass or opaque packaging to protect from light.
RU58841 Powder Packaging & Quality Control
Packaging Specifications
Small-Scale Supply: 1g, 5g, 10g, 50g, 100g aluminum foil bags (vacuum-sealed, nitrogen-flushed) or amber glass vials with desiccant.
Bulk Supply: 1kg, 5kg, 25kg sealed HDPE drums with inner aluminum foil liners; suitable for international shipping and industrial production.
Quality Standards
Complies with ISO 9001 and GMP guidelines; meets pharmaceutical-grade specifications for purity and impurities.
Heavy Metals Limit: Pb <10ppm, As <2ppm, Cd <1ppm, Hg <0.1ppm.
Microbial Control: Total aerobic bacteria <100 CFU/g; yeast & mold <10 CFU/g; Salmonella/Staphylococcus aureus: Negative.
Residual Solvents: Ethanol <0.5%, DMSO <0.1%, acetonitrile <0.041% (compliant with ICH Q3C guidelines).
Related Substances: Total impurities <1.0% (HPLC); no single impurity >0.5%.
RU58841 Powder Trade & Supply Notes
COA Availability: Certificates of Analysis (COA) are provided with each shipment, including purity (HPLC), melting point, heavy metals, microbial count, residual solvents, and related substances test results.
Customization: Bulk orders can be tailored for purity grades (98%/99%), packaging formats (e.g., vacuum-sealed bags, drum liners), and regulatory documentation (MSDS, REACH registration certificate, GMP compliance certificate, import/export declarations).
Transportation: Classified as a non-hazardous material (UN number not required); shipped under refrigerated conditions (2-8°C) for international transport to maintain stability. Avoid extreme temperatures (>25°C) and moisture during transit.
Storage Compatibility: Do not store with oxidizing agents, strong acids, or bases; keep in a cool, dry, dark environment. Avoid contact with incompatible materials to prevent degradation.
RU58841 Powder Test report - Yinherb Lab
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Yinherb Lab founded in 2009, has been deeply committed to the biotechnology field for over a decade. Today, it has established a professional development framework integrating "R&D + production" as an integrated system. And always adhered to the core business philosophy of "Quality First, Service Second, Price Third".
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