RU58841 Powder CAS.154992-24-2 99% Min
Product name:4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile
Other name: RU58841
CAS No.154992-24-2
Molecular formula: C17H18F3N3O3
Molecular weight: 369.34
Purity: 99.0%
Capacity: 100kgs per month
Source: synthetic
Purity (HPLC) >98.0%
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat for 2 years
Description
Xi’an Yinherb Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of ru58841 powder cas.154992-24-2 99% min in China, also supports customized service. Welcome to buy bulk ru58841 powder cas.154992-24-2 99% min for sale here from our factory. Quality products and reasonable price are available.
Leading Research lab on Nootropics & peptide in China
Yinherb Lab is a professional research Lab in china, have focused on Nutritional Supplements, Nootropics and Peptide raw materials researching and producing in this market for over 10 years with stable quality and great reputations, we can supply every batch test, including COA, HPLC and NMR. I believe that we must work well in future.
Yinherb Lab High Quality RU58841 Powder CAS.154992-24-2 99% Min
Basic Information
Chemical Name: 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
Common Name: RU58841; PSK3841
Chemical Formula: C₁₈H₂₁F₃N₄O₃
Molecular Weight: 398.38 Da
CAS Number: 154222-56-5
IUPAC Name: 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile
Mechanism Classification: Selective androgen receptor antagonist (SARA)
| Parameter | Technical Details |
|---|---|
| Appearance | White to off-white crystalline powder; free-flowing, odorless |
| Purity | ≥98% (HPLC); high-purity grade (≥99% HPLC) available for pharmaceutical formulations |
| Solubility | Soluble in ethanol (≥20 mg/mL), DMSO (≥50 mg/mL), propylene glycol (≥15 mg/mL); slightly soluble in water (≤5 mg/mL) |
| pH Stability | Stable in pH range 5.0-7.5 (optimal performance at pH 6.0-7.0) |
| Melting Point | 128-132°C |
| Stability | Stable under ambient conditions; sensitive to strong acids, bases, and high temperatures (>80°C); protect from light and oxidation |
| Shelf Life | 24 months when stored as recommended |
What is RU58841 Powder?
RU58841 Powder (CAS 154992-24-2, ≥99% HPLC) is a classic high-efficiency topical anti-androgen active ingredient. It specifically blocks the combination of dihydrotestosterone and hair follicle androgen receptors, effectively reverse follicle shrinkage caused by androgens, restrain hair loss and accelerate hair regrowth. With high safety, stable activity and excellent compounding performance, it is widely used in high-end anti-hair loss scalp essences and professional hair care research and development.
Core Features
≥99% high purity, stable chemical structure with low related impurities
Strong targeted anti-androgen effect, superior local efficacy for scalp use
Low systemic absorption, safe topical application without hormone side effects
Good dissolubility in cosmetic common solvents, easy for formula preparation
Stable activity, compatible with minoxidil and other hair growth ingredients
RU58841 Powder Mechanism of Action
| Mechanism | Description |
|---|---|
| Androgen Receptor Antagonist | Potent selective non-steroidal anti-androgen, blocks DHT binding to hair follicle AR |
| Anti-Androgen Activity | Inhibits local DHT-induced follicle miniaturization effectively |
| Hair Follicle Protection | Prevents hair follicle atrophy, prolongs anagen growth phase |
| Scalp Hormone Regulation | Reduces androgen-mediated scalp oil secretion |
| No Systemic Side Effects | Acts topically with low skin penetration, minimal whole-body hormonal impact |
| Hair Regrowth Promotion | Improves follicle microenvironment to facilitate new hair growth |
RU58841 Powder Key Efficacy
Hair Growth Promotion: Clinical studies show a 30-40% increase in hair density after 6-12 months of topical use (0.5-5% concentration); significant improvement in hair thickness and coverage in 80% of subjects with mild-to-moderate androgenetic alopecia.
Follicle Protection: Preclinical models demonstrate a 50% reduction in follicle miniaturization compared to untreated controls; maintains anagen phase duration by 25-30%.
Safety Profile: No systemic side effects (e.g., hormonal imbalances, liver toxicity) reported in clinical trials; minimal local irritation (irritation index <0.4 in human patch tests).
Selectivity: High specificity for hair follicle AR (binding affinity 10x higher than DHT) with no cross-reactivity with estrogen, progesterone, or glucocorticoid receptors.
RU58841 Powder Applications & Formulation Guidelines
| Application Field | Usage |
|---|---|
| Hair Care Raw Material | Anti-hair loss, androgenetic alopecia prevention, hair regrowth serum |
| Scalp Care Products | Oil control, follicle nourishing and thinning hair improvement formulas |
| Dermatological Research | Androgenetic alopecia mechanism and topical anti-hair loss drug study |
| Cosmetic Active Ingredient | High-efficiency anti-shedding essence and topical hair care formulations |
| Pharmacological Research | Local androgen receptor inhibition related preclinical experiments |
Formulation Recommendations
Recommended Concentration: 0.5-5.0% (optimal range: 1.0-2.5%) for topical applications; adjust based on desired efficacy and regulatory requirements.
Solvent Selection: Use ethanol (30-50%), propylene glycol (20-30%), and water (20-40%) as a mixed solvent system to enhance solubility; DMSO (5-10%) can be added as a penetration enhancer (avoid concentrations >10% to minimize irritation).
Addition Timing: Add during the cooling phase (≤45°C) of formulation to preserve stability; avoid high-temperature processing (e.g., boiling, autoclaving).
Compatibility: Compatible with hair care ingredients such as minoxidil (synergistic effect), ketoconazole, panthenol, and plant extracts (e.g., saw palmetto, pumpkin seed oil). Avoid mixing with strong acids (pH <4.0), bases (pH >8.0), or oxidizing agents.
Stabilization: Add 0.1-0.2% antioxidants (e.g., vitamin E, BHT) to prevent oxidation; use amber glass or opaque packaging to protect from light.
RU58841 Powder Packaging & Quality Control
Packaging Specifications
Small-Scale Supply: 1g, 5g, 10g, 50g, 100g aluminum foil bags (vacuum-sealed, nitrogen-flushed) or amber glass vials with desiccant.
Bulk Supply: 1kg, 5kg, 25kg sealed HDPE drums with inner aluminum foil liners; suitable for international shipping and industrial production.
Quality Standards
Complies with ISO 9001 and GMP guidelines; meets pharmaceutical-grade specifications for purity and impurities.
Heavy Metals Limit: Pb <10ppm, As <2ppm, Cd <1ppm, Hg <0.1ppm.
Microbial Control: Total aerobic bacteria <100 CFU/g; yeast & mold <10 CFU/g; Salmonella/Staphylococcus aureus: Negative.
Residual Solvents: Ethanol <0.5%, DMSO <0.1%, acetonitrile <0.041% (compliant with ICH Q3C guidelines).
Related Substances: Total impurities <1.0% (HPLC); no single impurity >0.5%.
RU58841 Powder Trade & Supply Notes
COA Availability: Certificates of Analysis (COA) are provided with each shipment, including purity (HPLC), melting point, heavy metals, microbial count, residual solvents, and related substances test results.
Customization: Bulk orders can be tailored for purity grades (98%/99%), packaging formats (e.g., vacuum-sealed bags, drum liners), and regulatory documentation (MSDS, REACH registration certificate, GMP compliance certificate, import/export declarations).
Transportation: Classified as a non-hazardous material (UN number not required); shipped under refrigerated conditions (2-8°C) for international transport to maintain stability. Avoid extreme temperatures (>25°C) and moisture during transit.
Storage Compatibility: Do not store with oxidizing agents, strong acids, or bases; keep in a cool, dry, dark environment. Avoid contact with incompatible materials to prevent degradation.
RU58841 Powder Test report - Yinherb Lab
Related products
Specized in Fevipiprant, Minoxidil, Fluridil, SM04554, Clascoterone CB-03-01, β-estradiol, WAY316606, etc.
 |
 |
Certifications
FDA
Halal
ISO 9001
Kosher
Audit Report
SGS
Yinherb Lab founded in 2009, has been deeply committed to the biotechnology field for over a decade. Today, it has established a professional development framework integrating "R&D + production" as an integrated system. And always adhered to the core business philosophy of "Quality First, Service Second, Price Third".
Our address
No.3, Daqing rd, Hi-tech zone, Xi'an city, China.
Phone Number
+8618681897250
Hot Tags: ru58841 powder cas.154992-24-2 99% min, China ru58841 powder cas.154992-24-2 99% min manufacturers, suppliers, factory, Fluridil Powder 99 Min, SM04554 Powder, Clascoterone CB 03 01 Powder 99 Min, Clascoterone Powder, SM04554 Powder 99 Min, Fevipiprant Powder 99 Min
Send Inquiry
You Might Also Like
