SM04554 Powder CAS.1360540-81-3 99% Min
Product name: SM04554 Powder
CAS No.1360540 - 81 - 3
Molecular formula: C₁₈H₁₆O₄
Molecular weight: 296.32
Purity: 99.0%
Capacity: 100kgs per month
Source: synthetic
Purity (HPLC) >98.0%
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat for 2 years
Description
Xi’an Yinherb Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of sm04554 powder cas.1360540-81-3 99% min in China, also supports customized service. Welcome to buy bulk sm04554 powder cas.1360540-81-3 99% min for sale here from our factory. Quality products and reasonable price are available.
Leading Research lab on Nootropics & peptide in China
Yinherb Lab is a professional research Lab in china, have focused on Nutritional Supplements, Nootropics and Peptide raw materials researching and producing in this market for over 10 years with stable quality and great reputations, we can supply every batch test, including COA, HPLC and NMR. I believe that we must work well in future.
Yinherb Lab High Quality SM04554 Powder CAS.1360540-81-3 99% Min
Product name: SM04554 Powder
Chemical Name: (E)-3-(4-Hydroxyphenyl)-2-(4-methoxyphenyl)acrylonitrile
CAS Number: 1360540-81-3
Molecular Formula: C₁₈H₁₆O₄
Molecular Weight: 296.32
Drug Class: Wnt signaling pathway activator (GSK-3β inhibitor)
Purity Standard: ≥99% (pharmaceutical/cosmetic grade, verified by HPLC/NMR)
Appearance: White crystalline powder, odorless
Solubility: Soluble in ethanol, chloroform, propylene glycol, and ethylenediamine; slightly soluble in diethyl ether; partially soluble in water
Stability: Stable under recommended storage conditions; sensitive to strong oxidation, extreme pH (＜5 or ＞8), and high temperature
Melting Point: Approximately 168–172°C (varies slightly by purity)
Log P (Octanol-Water Partition Coefficient): ~3.8 (25°C, pH 7.4)
What is SM04554 Powder?
SM04554 (Dalosirvat, CAS 1360540-81-3, ≥98% HPLC) is a potent, selective Wnt pathway activator powder for androgenetic alopecia research. It drives hair follicle regeneration, extends the anagen growth phase, and reverses follicle miniaturization-ideal for preclinical hair growth studies, topical formulation development, and Wnt signaling assays. Our high‑purity, stable product supports dermatology R&D and AGA drug discovery, trusted by global biotech and pharma research teams.
SM04554 Powder Mechanism of Action
GSK-3β Inhibition (Key Target)
SM04554 specifically inhibits glycogen synthase kinase-3β (GSK-3β), an enzyme that naturally suppresses the Wnt signaling pathway.Blocking GSK-3β removes this "brake" on Wnt activity, reactivating the pathway in hair follicle cells.
Wnt Pathway Activation (Follicle Growth Driver)
The Wnt pathway is critical for hair follicle development and cycling.Activated Wnt signaling initiates and extends the anagen (growth) phase of the hair cycle, preventing premature entry into the telogen (resting) phase.
Reverses Follicle Miniaturization
In androgenetic alopecia, Wnt pathway activity weakens over time, leading to progressive follicle miniaturization (thinning hairs).SM04554 restores Wnt function, prompting miniaturized follicles to revert to producing thick, terminal hairs.
Stimulates Progenitor Cell Differentiation
It induces dermal progenitor cells (hair follicle stem cells) to differentiate into hair bulge cells.This promotes the formation of new hair follicles and repairs damaged ones, enhancing overall hair density.
SM04554 Powder Applications & Formulation Guidelines
Hair loss treatment: It is mainly used as a raw material for topical anti-hair loss products to develop preparations such as serums and lotions targeting androgenetic alopecia. It can repair damaged hair follicles and promote hair regrowth. However, it should be noted that its developer, Biosplice Therapeutics (formerly Samumed), has stopped independent development for hair loss treatment and is exploring external authorization opportunities.
Tissue repair field: In addition to hair loss treatment, this powder also has potential application value in tissue repair and regeneration. It can promote the proliferation and differentiation of osteoblasts, enhance the repair ability of chondrocytes, and also inhibit tissue damage caused by inflammatory reactions. It has application prospects in cartilage injury repair, improving osteoarthritis and skin wound healing.
Comparison Table: Similar Hair Loss Treatment Ingredients
| Comparison Dimension | Fluridil Powder | Fevipiprant Powder | Minoxidil Powder | Finasteride Powder |
|---|---|---|---|---|
| Core Mechanism | Non-steroidal anti-androgen; blocks DHT binding to follicle receptors (no hormone modification) | CRTh2 antagonist; inhibits type 2 inflammation (targets inflammatory hair loss) | Potassium channel opener; prolongs anagen phase; promotes angiogenesis | 5α-reductase inhibitor; blocks testosterone → DHT conversion |
| Primary Indication | Androgenetic alopecia (male/female); hormonal-driven hair thinning | Asthma (primary); off-label for inflammatory alopecia (areata, seborrheic) | Androgenetic alopecia (male/female); diffuse thinning | Male androgenetic alopecia; benign prostatic hyperplasia (BPH) |
| Hair Loss Target Type | Hormonal-driven (androgenetic) | Inflammatory-mediated | Androgenetic + diffuse thinning | Hormonal-driven (male-specific) |
| Formulation Use | Topical (serums, lotions) | Oral (tablets); topical (R&D stage) | Topical (solutions/foams); oral (antihypertensive, off-label) | Oral (tablets); topical (in development) |
| Purity Standard | ≥98% (pharm/cosmetic grade) | ≥99% (pharmaceutical grade, USP/BP/EP) | ≥99% (pharmaceutical grade, USP/BP) | ≥99% (pharmaceutical grade, USP/BP) |
| Key Safety Risks | Mild scalp irritation (rare); no systemic/hormonal side effects | Mild skin/eye irritation; low acute toxicity; no reproductive risks (preclinical) | Topical: Scalp dryness/irritation; Oral: Hypotension, tachycardia | Oral: Sexual side effects; teratogenic (women of childbearing age) |
| Efficacy Timeline | 3–6 months (stabilization); 6–9 months (mild regrowth) | 3–6 months (emerging hair loss data); slower for inflammation | 3–6 months (regrowth); 12 months (max effect) | 3–6 months (stabilization); 6–12 months (regrowth) |
| Unique Advantages | Non-hormonal; safe for men/women; no systemic side effects | Targets unmet need (inflammatory alopecia); no hormonal interference | Gender-neutral; proven regrowth; widely available | Potent hormonal blocking; high efficacy for male pattern baldness |
| Limitations | Mild regrowth efficacy; less mainstream than minoxidil/finasteride | Limited clinical hair loss data; experimental use for alopecia | Daily application required; no effect on severe baldness | Male-only use; teratogenic risk; sexual side effects |
Quality Control
| QC Item | Method | Standard |
|---|---|---|
| Purity | HPLC | ≥98.0% |
| Identification | FT‑IR / SMILES | Conforms to reference |
| Loss on Drying | Gravimetry | ≤1.0% |
| Heavy Metals (Pb/Cd/As/Hg) | AAS | ≤10 ppm total |
| Residual Solvents | GC | ICH Q3C limits |
| Assay | HPLC | 97.0–103.0% |
| Appearance | Visual | Off‑white to pale yellow powder |
FAQ
| Question | Answer |
|---|---|
| Q1: Is SM04554 approved for human use? | A1: No; research use only (not FDA/EMA approved) |
| Q2: What concentrations are used clinically? | A2: 0.15% & 0.25% topical solutions (Phase 3) |
| Q3: MOQ & packaging? | A3: MOQ: 10 mg; 10 mg/100 mg/1 g/10 g in foil‑sealed vials |
| Q4: COA & MSDS available? | A4: Yes, full batch COA, MSDS, & HPLC data provided |
| Q5: Stability in formulations? | A5: Stable in DMSO/ethanol; avoid oxidation & light in topical gels |
| Q6: Samples for R&D? | A6: 5–10 mg research samples available upon request |
Related products
Specized in Fevipiprant, Minoxidil, Fluridil, SM04554, Clascoterone CB-03-01, β-estradiol, WAY316606, etc.
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Yinherb Lab founded in 2009, has been deeply committed to the biotechnology field for over a decade. Today, it has established a professional development framework integrating "R&D + production" as an integrated system. And always adhered to the core business philosophy of "Quality First, Service Second, Price Third".
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