KX-826 Powder CAS.1272719-00-2 99% Min
Product name: KX-826
CAS No.1272719-00-2
Molecular formula: C₂₁H₁₅F₅N₄O₂S
Molecular weight: 482.43 g/mol
Purity: 99.0%
Capacity: 100kgs per month
Source: synthetic
Purity (HPLC) >98.0%
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat for 2 years
Description
Xi’an Yinherb Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of kx-826 powder cas.1272719-00-2 99% min in China, also supports customized service. Welcome to buy bulk kx-826 powder cas.1272719-00-2 99% min for sale here from our factory. Quality products and reasonable price are available.
Leading Research lab on Nootropics & peptide in China
Yinherb Lab is a professional research Lab in china, have focused on Nutritional Supplements, Nootropics and Peptide raw materials researching and producing in this market for over 10 years with stable quality and great reputations, we can supply every batch test, including COA, HPLC and NMR. I believe that we must work well in future.
Yinherb Lab High Quality KX-826 Powder CAS.1272719-00-2 99% Min
| Parameter | Details |
|---|---|
| IUPAC Name | 4-[3-[4-cyano-2-fluoro-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]-2-fluoro-N-methylbenzamide |
| Common Names | KX-826, Pyrilutamide, SCHEMBL1444126, EX-A5504 |
| CAS Number | 1272719-00-2 (Free Base) |
| Molecular Formula | C₂₁H₁₅F₅N₄O₂S |
| Molecular Weight | 482.43 g/mol |
| Appearance | Off-white to light yellow crystalline powder |
| Purity (Typical) | ≥98% (HPLC) |
| Solubility | Soluble in DMSO, ethanol, propylene glycol; slightly soluble in water |
| Storage | 2–8°C, protected from light and moisture |
| Target | Androgen Receptor (AR) antagonist (IC₅₀ = 0.28 nM) |
What is KX-826 Powder?
KX‑826 (Pyrilutamide) is an innovative topical anti‑androgen developed by Kintor Pharmaceutical, designed specifically for androgenetic alopecia (AGA) and acne. By targeting and blocking DHT‑AR signaling directly at the hair follicle and sebaceous gland, KX‑826 effectively reduces follicle miniaturization, slows hair loss, and helps restore thicker, healthier hair.
KX‑826 Powder (CAS 1802998-33-0, ≥99% HPLC) is a potent, selective androgen receptor antagonist widely used in anti‑androgen and hair loss research. It blocks AR signaling, inhibits DHT‑driven pathways, and shows strong potential for androgenetic alopecia treatment development. Our high‑purity, stable grade ensures reliable results in cell assays and preclinical models.
KX-826 Powder Mechanism of Action
| Aspect | Description |
|---|---|
| Local AR Blockade | Competes with DHT for binding to androgen receptors (AR) in hair follicles and sebaceous glands, blocking DHT-mediated signaling, inhibiting follicular miniaturization, prolonging the anagen phase, and reducing sebum production. |
| Minimal Systemic Exposure | After topical application, KX-826 is rapidly metabolized to inactive metabolites, resulting in low systemic exposure and minimal impact on the hypothalamic-pituitary-gonadal (HPG) axis, thus avoiding systemic side effects associated with oral antiandrogens (e.g., sexual dysfunction). |
| Combination Synergy with Minoxidil | When used in combination with minoxidil, KX-826 shows synergistic effects on hair density. In clinical studies, the 24-week total non-vellus hair count (TAHC) in the combination group was approximately 10.24 hairs/cm² higher than in the minoxidil monotherapy group. |
KX-826 PowderClinical Status & Key Data
| Item | Details |
|---|---|
| Indications | Androgenetic alopecia (AGA) in men; acne vulgaris. Long-term safety study (52 weeks) completed in China; 0.5% twice-daily (BID) regimen shown to be safe and effective. |
| Key Trial Results | - 0.5% BID for 24 weeks: Significant increase in target area non-vellus hair count (TAHC) compared with baseline; overall safety profile was favorable, with mostly mild local adverse reactions (e.g., scalp pruritus, dryness).- Combination with 5% minoxidil: 24-week TAHC was 10.24 hairs/cm² higher than in the minoxidil alone group, demonstrating clear synergy. |
| Development Phase | In Phase III registration trials in China; positive data for combination therapy and higher-concentration monotherapy announced in 2025; new drug application (NDA) is under preparation. |
Comparison Table: KX‑826 Differs from Other Hair Loss Treatments
| Product | Mechanism | Route | Systemic Impact | Key Side Effects |
|---|---|---|---|---|
| KX-826 | Local androgen receptor (AR) antagonist | Topical | Low | Mild scalp irritation |
| Finasteride | 5α-reductase inhibitor (reduces DHT synthesis) | Oral | High | Potential sexual dysfunction, decreased libido, ejaculatory disorders |
| Minoxidil | Vasodilation and hair cycle modulation | Topical | Low | Scalp irritation, dryness, hypertrichosis in non-target areas |
Related products
Specized in Fevipiprant, Minoxidil, Fluridil, SM04554, Clascoterone CB-03-01, β-estradiol, WAY316606, etc.
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Yinherb Lab founded in 2009, has been deeply committed to the biotechnology field for over a decade. Today, it has established a professional development framework integrating "R&D + production" as an integrated system. And always adhered to the core business philosophy of "Quality First, Service Second, Price Third".
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