Tesofensine Powder CAS.402856-42-2 98% Min
Product name: Tesofensine
CAS No.: 402856 - 42 - 2; 195875 - 84 - 4 (isomer)
Molecular Formula: C₁₇H₂₃Cl₂NO
Molecular Weight:328.28 g/mol
Capacity: 500kgs per month
Source: synthetic
Purity (HPLC) >99.0%
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat for 2 years
Description
Xi’an Yinherb Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of tesofensine powder cas.402856-42-2 98% min in China, also supports customized service. Welcome to buy bulk tesofensine powder cas.402856-42-2 98% min for sale here from our factory. Quality products and reasonable price are available.
Leading Research lab on Nootropics & peptide in China
Yinherb Lab is a professional research Lab in china, have focused on Nutritional Supplements, Nootropics and Peptide raw materials researching and producing in this market for over 10 years with stable quality and great reputations, we can supply every batch test, including COA, HPLC and NMR. I believe that we must work well in future.
Yinherb Lab High Quality Tesofensine Powder CAS.402856-42-2 98% Min
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Product name |
Tesofensine |
| Chemical name | (2R,3S) - 3 - (3,4 - dichlorophenyl) - 2 - ethoxymethyl - 8 - methyl - 8 - azabicyclo[3.2.1]octane |
|
CAS No. |
402856 - 42 - 2; 195875 - 84 - 4 (isomer) |
|
Molecular formula |
C₁₇H₂₃Cl₂NO |
|
Molecular weight |
328.28 g/mol |
|
Purity |
≥98% (HPLC) |
|
Appearance |
White crystalline powder |
| Solubility | Soluble in ethanol, DMSO, oils; slightly soluble in water |
| Target & Potency | Dopamine (DA, IC₅₀=6.5 nM), Norepinephrine (NE, IC₅₀=1.7 nM), Serotonin (5 - HT, IC₅₀=11 nM) reuptake inhibition |
| Storage | Stable at 2–8°C, protect from light and oxidation; avoid high humidity. |
| Half - life | ~9 days (220 h), metabolized mainly by CYP3A4 |
What is Tesofensine Powder?
Tesofensine Powder (CAS 195455-69-7, ≥99% HPLC) is a potent triple monoamine reuptake inhibitor widely used in metabolic and neuroscience research. It effectively suppresses appetite, increases energy expenditure, and modulates central feeding pathways, making it ideal for obesity and body weight regulation studies. Our high‑purity, stable grade ensures reliable results in in vitro and in vivo assays. Strictly for research purposes only, trusted by global laboratories and pharmaceutical R&D teams.
High purity ≥99% (HPLC verified)
Potent triple reuptake inhibitor (5‑HT / NE / DA)
Strong appetite suppression and metabolic modulation
Stable under proper low‑temperature storage
Ideal for metabolic and neuroscience research only
Tesofensine Powder Mechanism of Action
| Mechanism of Action | Specific Functions & Details |
|---|---|
| Triple Neurotransmitter Regulation | Potently blocks the reuptake of dopamine (DA), norepinephrine (NE), and serotonin (5-HT) in the synaptic cleft; elevates their extracellular concentrations to enhance satiety, reduce hunger cravings, and increase resting energy expenditure (REE). |
| Hypothalamic Neuronal Modulation | Silences GABAergic neurons in the lateral hypothalamus (a key central feeding regulation center), further suppressing the intrinsic appetite drive. |
| Metabolic Enhancement | Promotes fat oxidation (showing a 15% increase within 24 hours); improves insulin sensitivity to regulate glucose metabolism; reduces adipose tissue volume without causing significant loss of lean body mass. |
Tesofensine Powder Key Applications &Dosage
| Category | Specific Details |
|---|---|
| Indications | Obesity (BMI ≥30 kg/m²); Obesity-related metabolic disorders (e.g., insulin resistance) |
| Recommended Dose | 0.25–0.5 mg/day (oral administration, once daily); Initiate at low dose and titrate upward gradually |
| Potential Off-Label Uses | Preclinical research on neuropsychiatric disorders (e.g., binge-eating disorder); Not yet clinically validated |
Tesofensine Advantages vs. Traditional Anti - Obesity Agents
| Feature | Tesofensine | Traditional Agents (e.g., Orlistat, GLP - 1 Agonists) |
|---|---|---|
| Mechanism | Central + metabolic dual - action | Peripheral (lipase inhibition) or single - pathway peptide agonism |
| Weight Loss Efficacy | Higher (5–10% in 24 weeks) | Moderate (3–5% in 24 weeks) |
| Duration of Action | Long (t₁/₂=9 days, once - daily dosing) | Short (t₁/₂=1–24 h, multiple daily dosing) |
| Metabolic Benefits | Improves insulin sensitivity, fat oxidation | Limited metabolic modulation |
Quality Control (QC)
| QC Item | Method | Standard |
|---|---|---|
| Purity | HPLC | ≥99.0% |
| Identity | LC‑MS / FT‑IR | Conforms to standard |
| Moisture | Karl Fischer | ≤0.5% |
| Heavy Metals (Pb/Cd/As/Hg) | AAS | Within regulatory limits |
| Related Substances | HPLC | Total impurities ≤1.0% |
| Total Plate Count | USP | ≤100 CFU/g |
| Salmonella / E. coli | USP | Negative |
FAQ
| Question | Answer |
|---|---|
| Q1: Is Tesofensine for human use? | A1: For research use only (RUO). Not for human, food, or clinical therapy. |
| Q2: What is the solubility? | A2: Soluble in DMSO, methanol, ethanol; limited water solubility. |
| Q3: What is the MOQ? | A3: MOQ: 10 mg; 10 mg / 100 mg / 1 g packs available. |
| Q4: Do you provide COA & MSDS? | A4: Yes, full COA, MSDS, HPLC, and LC‑MS data per batch. |
| Q5: How to store? | A5: Store at -20°C; avoid repeated freeze‑thaw cycles. |
| Q6: Are research samples available? | A6: Yes, small samples for R&D evaluation are available. |
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Yinherb Lab founded in 2009, has been deeply committed to the biotechnology field for over a decade. Today, it has established a professional development framework integrating "R&D + production" as an integrated system. And always adhered to the core business philosophy of "Quality First, Service Second, Price Third".
Our address
No.3, Daqing rd, Hi-tech zone, Xi'an city, China.
Phone Number
+8618681897250
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