O-304: Your Reliable Partner in Metabolic & Cardiovascular Research
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O-304: Your Reliable Partner in Metabolic & Cardiovascular Research
As a potent, oral-active pan-AMPK activator with 99% HPLC-verified purity, O-304 (CAS 1261289-04-6) is redefining research on type 2 diabetes, insulin resistance, and cardiovascular complications. Its unique mechanism of action and proven in vivo efficacy make it an indispensable tool for pharmaceutical R&D and academic studies.
🔍 Core Product Profile
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Parameter |
Details |
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Product Code |
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Chemical Name |
4-chloro-N-(2-(4-chlorobenzyl)-3-oxo-2,3-dihydro-1,2,4-thiadiazol-5-yl)benzamide |
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CAS Number |
1261289-04-6 |
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Purity |
≥99% (HPLC) |
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Appearance |
White crystalline powder |
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Molecular Formula |
C₁₆H₁₁Cl₂N₃O₂S |
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Molecular Weight |
380.2 g/mol |
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Solubility |
10 mg/mL in DMF |
💡 Why O-304 Stands Out for Your Research
1. Unique Mechanism: Targeted AMPK Activation Without ATP Depletion
O-304 activates AMP-activated protein kinase (AMPK) by suppressing dephosphorylation of AMPKα/β/γ trimers at threonine 172 - a distinct pathway that avoids reducing cellular ATP levels, eliminating confounding cytotoxic effects in cell models . This makes it ideal for long-term culture studies of metabolic regulation.
2. Proven In Vivo Efficacy in Metabolic Disease Models
Glucose Homeostasis: 100 mg/kg O-304 prevents high-fat diet-induced hyperglycemia and hyperinsulinemia in mice .
Insulin Sensitivity: Reverses insulin resistance by enhancing skeletal muscle AMPK phosphorylation .
Cardiovascular Protection: Improves microvascular perfusion in type 2 diabetes models, addressing comorbidity risks .
3. 99% Purity Ensures Reliable Results
Our O-304 exceeds industry standards (≥99% vs. typical 98%) to minimize batch-to-batch variation. Each lot undergoes rigorous HPLC testing, with full impurity profiling to eliminate interference in kinase assays and in vivo studies.
🎯 Key Research Applications
Leverage O-304's versatility across high-impact study areas:
Type 2 Diabetes Research: Mechanistic studies of insulin signaling and glucose metabolism.
Obesity & Metabolic Syndrome: Investigations into adipose tissue regulation and energy homeostasis.
Cardiovascular Complications: Research on microvascular dysfunction and AMPK-mediated cardioprotection.
Drug Discovery: Lead compound optimization for metabolic disease therapeutics (building on thiadiazole's proven pharmacophore potential ).
✅ Quality & Supply You Can Trust
Rigorous QC: Each batch includes a Certificate of Analysis (COA) with HPLC chromatograms and solubility data.
Stable Formulation: Crystalline solid form ensures 24-month stability when stored at -20°C, protected from light and moisture.
Flexible Sizing: Available in 10mg, 50mg, 100mg, and 1g quantities to match your project scale (bulk options for pilot studies).
Global Support: Fast shipping with complete documentation (MSDS, COA) for regulatory compliance.
Ready to Accelerate Your Research?
O-304's 99% purity, targeted AMPK activation, and proven in vivo efficacy make it the preferred choice for metabolic and cardiovascular research. Trust our expertise to deliver consistent, high-quality material that drives your discoveries forward.
👉 Contact us today for a custom quote, technical datasheet, or to request a sample.
Email: [sales@yinherblab.com] | WhatsApp: [+8618681897250]
