Acetyl Hexapeptide-37 Powder CAS.1447824-16-9 98% Purity Min

Xi’an Yinherb Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of acetyl hexapeptide-37 powder cas.1447824-16-9 98% purity min in China, also supports customized service. Welcome to buy bulk acetyl hexapeptide-37 powder cas.1447824-16-9 98% purity min for sale here from our factory. Quality products and reasonable price are available.

 

 

Yinherb Lab High Quality Acetyl Hexapeptide-37 Powder CAS.1447824-16-9 98% Purity

English Generic Name	Acetyl Hexapeptide-37 (Abbreviation: AH-37)
CAS Number	1447824-16-9
Molecular Classification	Synthetic Active Peptide (Acetylated Hexapeptide)
Amino Acid Sequence	Acetyl-Gly-Gln-Pro-Arg-Arg-Ala-NH₂ (N-terminal acetylation, C-terminal amidation)
Molecular Formula	C₂₇H₄₇N₁₁O₈
Molecular Weight	653.74 g/mol
Appearance	White to off-white crystalline powder, odorless
Purity Specifications	Industrial Grade ≥95% (HPLC), Pharmaceutical/High Purity Grade ≥98% (HPLC), Research Grade ≥99% (HPLC)
Key Quality Indicators	Moisture ≤5.0% (Karl Fischer), Heavy Metals ≤10 ppm, Total Bacterial Count ≤100 CFU/g, Endotoxin ≤0.5 EU/mg

 

Below is a detailed breakdown of Acetyl Hexapeptide 37 Powder Key Physicochemical Properties

1. Solubility

Water Solubility: Highly soluble in water (≥20 mg/mL at 25℃), forming a clear and transparent solution;

 

Organic Solvent Compatibility: Soluble in 40%-60% ethanol, propylene glycol, and glycerin (≥10 mg/mL); slightly soluble in methanol (≥2 mg/mL); insoluble in chloroform, ethyl acetate, and other non-polar solvents;

 

Dissolution Recommendations: Dissolve in deionized water first for aqueous formulations; for oil-in-water emulsions, pre-dissolve in glycerin (1:5 ratio) before adding to the aqueous phase to ensure uniform dispersion.

 

2. Stability

pH Stability: Stable within pH 4.5-8.5 (optimal pH range: 5.5-7.5 for cosmetic formulations); significant degradation may occur at pH<4.0 or pH>9.0;

 

Temperature Stability: Powder stable for 6 months at room temperature (≤25℃), 2 years at -20℃ (sealed); aqueous solutions stable for 3 months at 2-8℃, avoid storage above 30℃;

 

Compatibility Stability: Compatible with most cosmetic ingredients (e.g., hyaluronic acid, peptides, vitamins, plant extracts); avoid direct contact with strong oxidants (e.g., chlorine compounds) and reducing agents (e.g., sodium bisulfite);

 

Light Stability: Sensitive to strong UV light; store in opaque packaging to prevent photodegradation.

 

 

Acetyl Hexapeptide 37 Powder Core Efficacy & Mechanism of Action 

1. Main Efficacy (Validated by In Vitro Experiments & Formulation Tests)

Application Field	Core Efficacy	Data Support
Cosmetic Ingredients	Skin Hydration & Moisture Retention	Stimulates aquaporin-3 (AQP3) expression (68% increase in HaCaT cells); improves skin moisture content by 25%-35% after 21 days of use
Cosmetic Ingredients	Skin Barrier Repair	Promotes filaggrin (FLG) and ceramide synthesis; reduces transepidermal water loss (TEWL) by 20% in dry skin models
Cosmetic Ingredients	Soothing & Anti-Irritation	Inhibits TNF-α and IL-6 release (32% and 28% reduction respectively) in LPS-induced inflammatory cells
Topical Nutritional Supplements	Dry Skin Relief	Enhances skin natural moisturizing factor (NMF) production; effective for relieving xerosis and rough skin
Research Field	Skin Hydration Mechanism Studies	Regulates AQP3-mediated water transport pathway; applicable to dermatological research on barrier function

 

2. Mechanism of Action

Targets aquaporin-3 (AQP3) channels in keratinocytes, upregulating their expression to enhance intercellular water transport and improve skin hydration at the cellular level;

 

Activates the PPAR-α signaling pathway in epidermal cells, promoting the synthesis of barrier-related proteins (FLG, involucrin) and lipids (ceramides, cholesterol), strengthening the stratum corneum barrier;

 

Inhibits the activation of NF-κB signaling pathway, reducing the release of pro-inflammatory cytokines and alleviating skin inflammation caused by external stimuli (e.g., dryness, irritation).

 

 

Application Scenarios & Technical Requirements

1. Cosmetic Formulation Applications

Suitable Products: Moisturizing creams, hydrating serums, barrier repair lotions, sensitive skin care products, body lotions, and after-sun repair products;

Recommended Dosage: 0.01%-0.15% (100-1500 ppm); optimal dosage for dry skin formulations: 0.05%-0.1%;

Formulation Process: Add in the final stage of formulation (temperature <45℃) to preserve peptide activity; compatible with humectants (e.g., glycerin, sodium hyaluronate), emollients (e.g., squalane), and soothing ingredients (e.g., panthenol) for synergistic effects;

Stability Optimization: Add 0.2%-0.4% EDTA disodium to chelate heavy metals; use opaque packaging (e.g., amber glass bottles, aluminum tubes) to avoid light exposure; add 0.3%-0.5% phenoxyethanol as a preservative for aqueous formulations.

 

2. Research & Custom Synthesis Applications

Cell Experiments: Recommended working concentration: 5-50 μM; applicable to HaCaT cells, human epidermal keratinocytes, and dermal fibroblasts;

Custom Synthesis: Supports modifications (e.g., fluorescent labeling, biotinylation, amino acid substitution); minimum custom order: 1g; bulk production capacity: up to 10 kg/batch;

Quality Control: Research-grade products provide HPLC purity, MS identification, and amino acid composition analysis reports; pharmaceutical-grade products comply with USP/EP peptide quality standards.

 

3. International Trade Compliance Requirements (for US, Canada, EU Markets)

United States: Complies with FDA's Cosmetic Ingredient Review (CIR) requirements; "active peptide ingredient" labeling required for OTC cosmetics;

European Union: Listed in the CosIng database (No. 18393); usable in general cosmetics without additional registration;

Canada: Complies with Health Canada's Cosmetic Regulations; COA (Certificate of Analysis) and MSDS (Material Safety Data Sheet) required, ensuring heavy metal (lead, mercury) content meets limits (<10 ppm).

 

Acetyl Hexapeptide 37 Powder Storage Conditions

1. Storage Conditions

Powder Form: Store in a sealed, opaque container; keep in a cool, dry, and dark environment (-20℃ recommended for long-term storage, shelf life 2 years); avoid moisture, light, and high temperatures;

Solution Form: Prepare fresh before use; if stored, adjust pH to 5.5-7.5, add 0.05% preservative, and refrigerate at 2-8℃ (shelf life 1 month); avoid repeated freeze-thaw cycles.

 

2. Packaging Specifications (Customizable)

Specification	Packaging Material	Application Scenario
1g/5g/10g	Borosilicate glass bottle (with sealed cap)	Scientific research, small-batch formulation testing
100g/500g	Vacuum-sealed aluminum foil bag	Pilot-scale production, customer sample trials
1kg/5kg/25kg	Food-grade HDPE drum (with inner moisture-proof bag)	Large-scale production, international trade and transportation
Custom Specifications	Material customizable (sterile packaging available)	Pharmaceutical-grade ingredients, special formulation requirements

 

Hot Tags: acetyl hexapeptide-37 powder cas.1447824-16-9 98% purity min, China acetyl hexapeptide-37 powder cas.1447824-16-9 98% purity min manufacturers, suppliers, factory, Acetyl Hexapeptide 38 Powder 98 Purity Min, CAS 1447824 16 9, CAS 72957 37 0, L Ergothioneine Powder CAS 497 30 3 99 Purity Min, Oligopeptide 1 Powder 99 Purity Min, Pure L Carnosine Powder CAS 305 84 0 98 Purity Min