Eptifibatide Powder CAS. 188627-80-7 99% Purity Min factory
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Eptifibatide Powder CAS. 188627-80-7 99% Purity Min
English Name：Eptifibatide powder
CAS No.: 188627-80-7
Molecular Weight：700.78g/mol
Molecular Formula：C₂₈H₄₃N₁₁O₉S
Appearance：White powder
Odor: no
Stability: stable
MSDS and COA: available for your reference
Capacity: 500g per month
Appearance: white powder
Source: synthetic
Purity (HPLC) >98.0%
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 10g
Storage: Store in cool & dry place, Keep away from strong light and heat for 2 years
Description
Xi’an Yinherb Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of eptifibatide powder cas. 188627-80-7 99% purity min in China, also supports customized service. Welcome to buy bulk eptifibatide powder cas. 188627-80-7 99% purity min for sale here from our factory. Quality products and reasonable price are available.
Leading Research lab on Nootropics & peptide in China
Yinherb Lab is a professional research Lab in china, have focused on Nutritional Supplements, Nootropics and Peptide raw materials researching and producing in this market for over 10 years with stable quality and great reputations, we can supply every batch test, including COA, HPLC and NMR. I believe that we must work well in future.
Yinherb Lab High Quality Eptifibatide powder CAS. 188627-80-7 99% Purity Min
Generic Name: Eptifibatide powder
CAS Number: 188627-80-7
Molecular Formula: C₂₈H₄₃N₁₁O₉S
Molecular Weight: 700.78 (excluding acetate)
Amino Acid Squence: H-Cys(1)-Asn(2)-Gly(3)-Asp(4)-Trp(5)-Pro(6)-Cys(7)-NH₂ (disulfide bridge between Cys1 and Cys7)
Appearance: White to off-white lyophilized powder
Solubility: highly soluble in water (≥50 mg/mL) and physiological saline, slightly soluble in methanol
Quality indicators: Complies with peptide drug standards, bacterial endotoxin ≤10 EU/mg, water content ≤8.0%, no detectable pyrogens or heavy metals (≤10 ppm).
Purity Requirement: Common purity specification ≥98% (HPLC), total impurity content ≤2.0%
What is Eptifibatide powder?
Eptifibatide Powder (CAS 188627-80-7, ≥99% HPLC) is a cyclic heptapeptide derived from rattlesnake venom, serving as a high-selectivity GP IIb/IIIa receptor antagonist. It reversibly inhibits platelet aggregation, effectively preventing thrombosis in ACS and PCI settingsFDA Access Data. With high purity, stable quality, and reliable safety, it is widely used as a key raw material for antithrombotic injection formulations and cardiovascular research.
Core Features
High-purity cyclic heptapeptide with potent, reversible antiplatelet activity;
high selectivity for GP IIb/IIIa receptor, minimal off-target effects;
rapid onset and short duration, allowing precise clinical control;
low immunogenicity compared to antibody-based GP IIb/IIIa inhibitors; compatible with common anticoagulants (heparin) and antiplatelet agents (aspirin, clopidogrel).
Eptifibatide powder Mechanism of Action and Additional Efficacy
| Mechanism | Description |
|---|---|
| GP IIb/IIIa Receptor Antagonist | Reversibly binds to platelet glycoprotein IIb/IIIa receptor, blocking fibrinogen and von Willebrand factor bindingFDA Access Data |
| Inhibit Platelet Aggregation | Prevents platelet cross-linking and aggregation, reducing thrombosis riskFDA Access Data |
| Rapid Reversibility | Short half-life; platelet function recovers ~6 hours after discontinuation |
| Antithrombotic Effect | Potently inhibits platelet activation, critical for acute coronary syndrome (ACS) intervention |
Eptifibatide powder Application
Acute Coronary Syndrome (ACS):
Used for patients with unstable angina pectoris or non-ST-segment elevation myocardial infarction (NSTEMI), whether undergoing percutaneous coronary intervention (PCI) or receiving medical treatment alone.
Reduces the risk of death, myocardial infarction, or refractory ischemia within the short term (30 days) by inhibiting platelet aggregation.
Percutaneous Coronary Intervention (PCI):
Administered before or during PCI (e.g., stent implantation) to prevent acute thrombotic occlusion of the treated coronary artery.
Improves the success rate of the procedure and reduces postoperative ischemic complications such as myocardial infarction or target vessel revascularization.
Other Ischemic Cardiovascular Diseases:
Investigated in research for preventing thrombosis in patients with acute myocardial infarction (STEMI) undergoing thrombolytic therapy, or for high-risk patients with coronary artery bypass grafting (CABG).
Quality Control (QC)
| Test Item | Method | Standard |
|---|---|---|
| Purity | HPLC | ≥98.0% / ≥99.0% |
| Identity | LC-MS, NMR, FT-IR | Matches reference standard |
| Loss on Drying | Karl Fischer | ≤0.5% |
| Heavy Metals | ICP-MS | Pb < 10 ppm; As < 2 ppm (USP/EP compliant) |
| Related Substances | HPLC | Total impurities ≤1.0% |
| Sterility | Membrane filtration | Compliant with pharmacopeia standardsFDA Access Data |
Here's a detailed comparison table of Eptifibatide and Other GP IIb/IIIa Antagonists:
| Comparison Item | Eptifibatide | Tirofiban | Abciximab |
|---|---|---|---|
| Type & Structure | Synthetic cyclic peptide, selective GP IIb/IIIa antagonist | Synthetic non-peptide, selective GP IIb/IIIa antagonist | Monoclonal antibody fragment (chimeric), non-selective GP IIb/IIIa antagonist |
| CAS Number | 148031-34-9 | 144494-65-5 | 108196-89-6 |
| Molecular Weight | 700.78 | 495.08 | 47615-71-4 (approximate) |
| Purity Specification | ≥98% (HPLC), total impurities ≤2.0% | ≥98% (HPLC), total impurities ≤2.0% | ≥97% (HPLC), total impurities ≤3.0% |
| Route of Administration | IV bolus + continuous infusion | IV bolus + continuous infusion | IV bolus + continuous infusion |
| Core Advantages | High selectivity for GP IIb/IIIa, rapid onset/offset, low immunogenicity | Short half-life (≈2 hours), easy to adjust dosage, low risk of antibody formation | Strongest binding affinity to GP IIb/IIIa, long-lasting effect (half-life ≈12 hours) |
| Limitations | Renal excretion-dependent, dosage adjustment needed for renal impairment | Weaker antiplatelet effect than Abciximab, shorter duration of action | Immunogenicity (risk of antibody formation), longer recovery of platelet function |
| Bleeding Risk | Moderate (lower than Abciximab, higher than Tirofiban) | Lowest among the three | Highest (risk of severe bleeding such as intracranial hemorrhage) |
| Clinical Application Scope | ACS (with/without PCI), STEMI (research), PCI adjuvant | ACS (with/without PCI), PCI adjuvant | Mainly PCI (especially complex lesions), refractory ACS |
| Price Range (1mg) | Domestic: ~¥200–300; International: ~$150–250 | Domestic: ~¥150–250; International: ~$100–200 | Domestic: ~¥500–800; International: ~$300–500 |
Related products
Specized in Semaglutide, Tirzepatide, Retatrutide, DSIP, Epitalone, Selank, Semax, Melanotan II, Thymosin alpha 1, Oxytocin, P21, Adamax, Dihexa and son on.
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Yinherb Lab founded in 2009, has been deeply committed to the biotechnology field for over a decade. Today, it has established a professional development framework integrating "R&D + production" as an integrated system. And always adhered to the core business philosophy of "Quality First, Service Second, Price Third".
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No.3, Daqing rd, Hi-tech zone, Xi'an city, China.
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