Ibudilast Powder CAS.50847-11-5 98% Min
Product name: Ibudilast
CAS No.: 50847-11-5
Molecular Formula: C₁₄H₁₈N₂O
Molecular Weight: 230.31 g/mol
Capacity: 500kgs per month
Source: synthetic
Purity (HPLC) >99.0%
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat for 2 years
Description
Xi’an Yinherb Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of ibudilast powder cas.50847-11-5 98% min in China, also supports customized service. Welcome to buy bulk ibudilast powder cas.50847-11-5 98% min for sale here from our factory. Quality products and reasonable price are available.
Leading Research lab on Nootropics & peptide in China
Yinherb Lab is a professional research Lab in china, have focused on Nutritional Supplements, Nootropics and Peptide raw materials researching and producing in this market for over 10 years with stable quality and great reputations, we can supply every batch test, including COA, HPLC and NMR. I believe that we must work well in future.
Yinherb Lab High Quality Ibudilast Powder CAS.50847-11-5 98% Min
| Parameter | Details |
|---|---|
| IUPAC Name | 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine |
| Common Names | Ibudilast, AV-411, MN-166, KC-404 |
| CAS Number | 50847-11-5 |
| Molecular Formula | C₁₄H₁₈N₂O |
| Molecular Weight | 230.31 g/mol |
| Appearance | White crystalline powder; slightly soluble in water, soluble in organic solvents |
| Purity (Typical) | ≥99% (HPLC) |
| Storage | Store at 2–8°C, protect from light/moisture; stable for 2 years under recommended conditions |
| Primary Targets | PDE4 (IC₅₀=0.08 μM), PDE2 (0.11 μM), PDE5 (2.2 μM); TLR4 antagonist |
What is Ibudilast Powder?
Ibudilast Powder (CAS 50847-11-5, ≥99% HPLC) is a potent phosphodiesterase inhibitor widely used in neurological and inflammatory research. It suppresses microglial activation, reduces pro‑inflammatory cytokines, and provides strong neuroprotective effects. Ideal for studies on neuropathic pain, neuroinflammation, asthma, and CNS disorders, our high‑purity grade ensures reliable and reproducible results in vitro and in vivo. Strictly for research purposes only, trusted by global labs and pharmaceutical R&D teams.
High purity ≥99% (HPLC verified)
Dual PDE4 / PDE10 inhibitor with strong anti‑neuroinflammatory activity
Well‑documented neuroprotective and immunomodulatory profile
Stable under recommended storage conditions
Ibudilast Powder Key Features
• Powerful PDE4 Inhibition
Potently blocks PDE4 (IC₅₀ = 0.08 μM), reducing inflammation and improving respiratory and neurological function.
• Broad‑Spectrum Anti‑Inflammatory Action
Lowers pro‑inflammatory cytokines (TNF‑α, IL‑6, IL‑1β) and modulates TLR4 signaling for systemic inflammation control.
• Neuroprotective & Brain‑Penetrating
Crosses the blood‑brain barrier to reduce microglial activation, support neuronal survival, and improve neuroimmune balance.
• Dual Activity: Respiratory + Neurological
Effective for asthma, allergic disorders, post‑stroke symptoms, and neuroinflammatory conditions.
• Excellent Safety Profile
Low systemic burden with minimal side effects; no steroid‑like risks.
• Pharmaceutical‑Grade Purity
≥99% purity (HPLC), suitable for formulations, clinical research, and commercial manufacturing.
• Stable & Easy to Formulate
Compatible with oral capsules, tablets, ophthalmic solutions, and sustained‑release formulations.
• Versatile Research Tool
Widely used in studies of neurodegeneration, addiction, neuroinflammation, and respiratory diseases.
Ibudilast Powder Mechanism of Action
| Action Pathway | Key Effects |
|---|---|
| PDE Inhibition | Blocks PDE4 (potent), PDE2/3/5/10/11; elevates cAMP/cGMP to relax bronchial smooth muscle, dilate cerebral vessels, and inhibit platelet aggregation |
| TLR4 Antagonism | Reduces neuroinflammation by blocking TLR4 signaling; lowers pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) and boosts anti-inflammatory IL-10 |
| Neuroimmune Modulation | Crosses the blood-brain barrier; inhibits microglial activation, upregulates neurotrophins (GDNF, NGF), and protects neurons from excitotoxicity |
| Allergy & Inflammation | Antagonizes leukotriene D4 (LTD4) and PAF; reduces allergic reactions and vascular permeability |
Ibudilast Powder Approved Indications & Emerging Uses
| Category | Indications | Route & Dosing |
|---|---|---|
| Approved (Japan/Korea) | - Bronchial asthma (oral capsules, 10 mg BID)- Post-stroke dizziness (chronic cerebral circulation impairment)- Allergic conjunctivitis/hay fever (ophthalmic solution) | Oral (10 mg capsules, BID); topical (ophthalmic drops) |
| Emerging Research | - Neurodegenerative diseases (multiple sclerosis, neuroinflammatory pain)- Addiction (alcohol, opioid, methamphetamine dependence)- Neuroprotective adjuvant in stroke/TBI | Investigational oral formulations (up to 30 mg/day) |
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Yinherb Lab founded in 2009, has been deeply committed to the biotechnology field for over a decade. Today, it has established a professional development framework integrating "R&D + production" as an integrated system. And always adhered to the core business philosophy of "Quality First, Service Second, Price Third".
Our address
No.3, Daqing rd, Hi-tech zone, Xi'an city, China.
Phone Number
+8618681897250
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