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IDRA-21 Powder CAS.22503-72-6 99% Min

Name: China IDRA-21 Powder CAS.22503-72-6 99% Min Manufacturers Suppliers Factory - Good Price - yinherb
Brand: yinherb
SKU: 286812875

Product name: IDRA-21
CAS No.: 22503-72-6
Molecular Formula: C₈H₉ClN₂O₂S
Molecular Weight: 232.68–232.7
Density: 1.17g/cm3
Boiling point: 367.3°C at 760 mmHg
Flash point: 175.9°C
Refractive index: 1.658
Capacity: 500kgs per month
Source: synthetic
Purity (HPLC) >99.0%
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat for 2 years

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Description

Xi’an Yinherb Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of idra-21 powder cas.22503-72-6 99% min in China, also supports customized service. Welcome to buy bulk idra-21 powder cas.22503-72-6 99% min for sale here from our factory. Quality products and reasonable price are available.

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Yinherb Lab is a professional research Lab in china, have focused on Nutritional Supplements, Nootropics and Peptide raw materials researching and producing in this market for over 10 years with stable quality and great reputations, we can supply every batch test, including COA, HPLC and NMR. I believe that we must work well in future.

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Yinherb Lab High Quality IDRA-21 Powder CAS.22503-72-6 99% Min

Product name	IDRA-21 Powder
Other name	7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide
CAS No.	22503-72-6
Molecular formula	C₈H₉ClN₂O₂S
Molecular weight	232.68–232.7g/mol
Purity	≥98% (HPLC-verified), with high-purity grades up to 99%+ available
Appearance	Off-white crystalline powder or lyophilized powder
Solubility	Soluble in DMSO (100 mM / ~47 mg/mL at 25°C) - Slightly soluble in ethanololuble in water
Structural Feature	Benzothiadiazine ring with chloro, methyl, and dioxide substituents-critical for AMPA receptor binding and blood-brain barrier penetration
Application	Nootropic

What is IDRA-21 Powder?

IDRA-21 Powder (CAS 22503-72-6, ≥99% HPLC) is a high-purity, orally active AMPA receptor positive allosteric modulator (ampakine) belonging to the benzothiadiazine class. It enhances glutamatergic synaptic transmission and plasticity, effectively boosting learning, memory and cognitive flexibility while exerting neuroprotective effects. Widely used in cognitive neuroscience, neuropharmacology and psychiatric disorder research, it is an essential tool compound for exploring AMPA receptor function and developing novel nootropic drugs.

Core Features

High-purity research-grade powder with excellent batch consistency and low residual impurities

Highly potent, orally active AMPA modulator with no significant neurotoxicity

Enhances cognitive functions at low doses without receptor desensitization

Stable chemical structure under standard storage conditions; easy to handle in labs

Widely cited in top journals (e.g., Nature, Cell) for high reliability

Large enterprise scale

wide Products Line

high-quality customized service

IDRA-21

IDRA-21 Powder Benefits and Function

Its biological effects stem from selective interaction with AMPA receptors-ionotropic glutamate receptors central to fast excitatory synaptic transmission and memory formation:

Inhibits Receptor Desensitization: Binds to an allosteric site on AMPA receptors (e.g., GluA1/2 subtypes) to slow desensitization during prolonged glutamate exposure. This prolongs receptor activation, enhancing Na⁺/Ca²⁺ ion influx into neurons.

Strengthens Synaptic Plasticity: By sustaining AMPA receptor activity, it promotes long-term potentiation (LTP)-the molecular basis of learning and memory-especially in the hippocampus (a brain region critical for memory consolidation).

Superior BBB Penetration: More effective at crossing the blood-brain barrier than related compounds (e.g., cyclothiazide), ensuring efficient access to central nervous system (CNS) targets.

Cognitive Enhancement (Primary Activity)

Memory & Learning Improvement: In preclinical models (e.g., patas monkeys, rodents), it reverses pharmacologically induced cognitive impairments and boosts spatial memory/associative learning . At 70μM, it doubles glutamate-induced charge transfer in GluA1/2-expressing cells, indicating enhanced synaptic signaling .

Mood & Focus Support: Preliminary data suggests it improves mood and sensory perception by strengthening glutamatergic synapses in brain regions linked to attention.

IDRA-21

IDRA-21 Powder Application

Application Field	Usage
Cognitive Research	Memory/learning mechanism studies, aging-related cognitive impairment models
Neuropharmacology	AMPA receptor function, synaptic transmission and plasticity research
Psychiatric Research	Depression, anxiety and schizophrenia-related mechanism exploration
Nootropic Development	Preclinical research for novel cognitive-enhancing drugs
Laboratory Standard	Reference substance for receptor pharmacology and drug screening assays

FAQ

Question	Answer
Water Solubility	Insoluble in water; soluble in DMSO/ethanol for in vitro/in vivo use
Core Advantage	Potent ampakine with cognitive enhancement and neuroprotective effects
MOQ & Sample	10–50 g sample available; bulk 1 kg+ supply supported
Supporting Documents	COA, HPLC, NMR, LC-MS, MSDS complete batch documents
Shelf Life	36 months when sealed and stored at -20°C; 6 months at 4°C

Certifications

FDA

Halal

ISO 9001

Kosher

Audit Report

SGS

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Yinherb Lab founded in 2009, has been deeply committed to the biotechnology field for over a decade. Today, it has established a professional development framework integrating "R&D + production" as an integrated system. And always adhered to the core business philosophy of "Quality First, Service Second, Price Third".

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