Coluracetam Powder CAS.135463-81-9 99% Purity
Product name: Coluracetam Powder
CAS No.: 135463-81-9
Molecular Formula: C₁₅H₁₈N₂O₄
Molecular Weight: 290.32 g/mol
Capacity: 500kgs per month
Source: synthetic
Purity (HPLC) >99.0%
Place of Origin: China Yinherb-Lab
Packing: As per client's requirements
Minimum Order Quantity: 1kg
Storage: Store in cool & dry place, Keep away from strong light and heat for 2 years
Description
Xi’an Yinherb Bio-Tech Co., Ltd. is one of the leading manufacturers and suppliers of coluracetam powder cas.135463-81-9 99% purity in China, also supports customized service. Welcome to buy bulk coluracetam powder cas.135463-81-9 99% purity for sale here from our factory. Quality products and reasonable price are available.
Leading Research lab on Nootropics & peptide in China
Yinherb Lab is a professional research Lab in china, have focused on Nutritional Supplements, Nootropics and Peptide raw materials researching and producing in this market for over 10 years with stable quality and great reputations, we can supply every batch test, including COA, HPLC and NMR. I believe that we must work well in future.
Yinherb Lab High Quality Coluracetam Powder CAS.135463-81-9 99% Purity
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Product name |
Coluracetam |
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Chemical name |
(R)-2-[(2-Oxopyrrolidin-1-yl)acetamido]-3-phenylpropanoic acid |
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CAS No. |
135463-81-9 |
|
Molecular formula |
C₁₅H₁₈N₂O₄ |
|
Molecular weight |
290.32 g/mol |
|
Purity |
≥98–99% (research grade, HPLC/LC-MS) |
|
Appearance |
White to off-white crystalline powder |
| Solubility | Slightly soluble in water; soluble in DMSO, ethanol, and acetone |
| Bioavailability | ~30–50% (oral administration); crosses the blood-brain barrier rapidly |
| Storage | 2–8°C, sealed, dark container; stable for ≥2 years |
|
Application |
Nootropic |
What is Coluracetam Powder?
Coluracetam Powder (CAS 135463-81-9, ≥99% HPLC) is a high-efficiency novel nootropic raw material with a unique high-affinity choline uptake activation mechanism. It significantly increases acetylcholine concentration in the brain, optimizes hippocampal synaptic transmission, enhances memory consolidation, mental focus and cognitive clarity while providing reliable neuroprotective effects. Widely used in global cognitive neuroscience labs and advanced brain health formula research, with stable high purity and strict quality assurance.
Ultra-high purity ≥99% HPLC certified raw powder
Unique HACU targeted mechanism, different from common racetams
Excellent blood–brain barrier penetration efficiency
Stable crystal structure, low moisture & strict impurity control
Pure research-grade material for lab & formulation development only
Coluracetam Powder Mechanism of Action
Coluracetam's mechanism is more targeted than other racetams, with two primary pathways:
High-Affinity Cholinergic Modulation
--Acts as a positive allosteric modulator (PAM) of the choline transporter (CHT)-the protein responsible for reuptaking choline into cholinergic neurons to synthesize acetylcholine (ACh). This increases ACh synthesis and release in brain regions critical for memory (hippocampus) and attention (prefrontal cortex).
--Unlike other racetams, it does not directly modulate NMDA/AMPA receptors; its cognitive effects are primarily cholinergic-driven.
Neuroprotective Effects
--Preclinical studies show it preserves cholinergic neuron function in models of age-related cognitive decline and neurodegeneration (e.g., Alzheimer's disease). It reduces oxidative stress and inhibits neuronal apoptosis by upregulating antioxidant enzymes (e.g., SOD, GPx).
--May enhance synaptic plasticity by supporting nerve growth factor (NGF) expression, which promotes neuronal survival and connection formation.
Coluracetam Powder Key Cognitive Effects & Applications
--Cognitive Enhancement (Healthy Adults)
Memory & Learning: Boosts working memory, verbal recall, and long-term memory consolidation-effects are more pronounced than piracetam or pramiracetam in small human trials.
Attention & Focus: Reduces mental fatigue and improves sustained attention, making it useful for tasks requiring prolonged concentration (e.g., studying, complex work).
Mood Regulation: Some users report reduced anxiety and improved mood, likely due to enhanced cholinergic signaling in the prefrontal cortex (linked to emotional regulation).
--Potential Off-Label/Preclinical Applications
Age-Related Cognitive Decline (ARCD) & Mild Cognitive Impairment (MCI): Preclinical data shows it preserves cholinergic neuron function and reverses memory deficits in aged animal models. Limited human data suggests improvements in memory and daily functioning in MCI patients.
Alzheimer's Disease (AD): Investigated as an adjunct to AChE inhibitors (e.g., galantamine) to enhance cholinergic signaling-preclinical models show reduced amyloid-beta plaque accumulation and improved cognitive performance. Not approved for AD treatment.
Glaucoma: Preclinical studies suggest it may protect retinal ganglion cells from damage by reducing oxidative stress-explored as a potential neuroprotective agent for ocular neurodegeneration.
FAQ
| Question | Answer |
|---|---|
| Q1: Water solubility? | A1: Slightly soluble in water; easy dissolved in DMSO/ethanol for stock solutions. |
| Q2: Core advantage? | A2: Specific enhancement of high-affinity choline uptake, gentle & efficient memory improvement. |
| Q3: MOQ & samples? | A3: Small 10–50g test samples available; MOQ 1kg, bulk 25kg stock supply. |
| Q4: Document support? | A4: COA, HPLC, NMR, LC-MS, MSDS complete batch documents provided. |
| Q5: Shelf life? | A5: 24 months sealed cool dry away from light under standard storage. |
Side-by-Side Comparison: Coluracetam vs. Major Racetams
| Feature | Coluracetam (BCI-540) | Piracetam (Original Racetam) | Aniracetam | Pramiracetam |
|---|---|---|---|---|
| Chemical Class | Synthetic racetam | Synthetic racetam | Synthetic racetam | Synthetic racetam |
| CAS Number | 135463-81-9 | 7491-74-9 | 72432-10-1 | 68497-62-1 |
| Molecular Weight | 290.32 g/mol | 142.16 g/mol | 219.24 g/mol | 296.32 g/mol |
| Potency (Human Dose) | Very high0.1–0.6 mg/day (divided 1–2x)Extremely potent; low doses sufficient | Low1200–4800 mg/day (divided 2–3x)Lowest potency; requires high doses | Moderate750–1500 mg/day (divided 2x)Mid-range potency | Moderate–High400–1200 mg/day (divided 1–2x)10–30x stronger than piracetam |
| Core Mechanism of Action | Cholinergic-focused:Positive allosteric modulator (PAM) of choline transporters (CHT); boosts acetylcholine (ACh) synthesis/release in hippocampus/prefrontal cortexNo direct NMDA/AMPA modulation | Broad, less defined:Enhances membrane fluidity; mild cholinergic modulation; weak glutamatergic effectsNo specific receptor targets identified | Glutamatergic + cholinergic:AMPA receptor modulator; boosts ACh release; enhances synaptic plasticityAlso modulates dopamine/serotonin (mood effects) | Cholinergic + glutamatergic:Enhances ACh utilization; modulates NMDA/AMPA receptors; increases neuronal membrane fluidity |
| Primary Cognitive Effects | - Targeted working memory & verbal recall improvement- Reduces mental fatigue- Mild anxiolytic-like mood support | - General cognitive enhancement (modest)- Improves memory consolidation in elderly- Reduces brain fog | - Enhances episodic memory & focus- Reduces anxiety (key differentiator)- Mitigates stress-induced cognitive decline | - Strong working/episodic memory boost- Enhances sustained attention & learning efficiency- Reduces mental fatigue during long tasks |
| Neuroprotective Effects | - Preserves cholinergic neuron function in aging/AD models- Reduces oxidative stress in retinal ganglion cells (glaucoma research) | - Mild neuroprotection in ischemia models- Supports membrane repair in neurons | - Reduces glutamate-induced excitotoxicity- Protects against age-related neuronal loss | - Reduces oxidative stress in TBI models- Preserves synaptic plasticity in aging brains |
| Solubility | Slightly soluble in water; soluble in DMSO, ethanol, acetone | Soluble in water, DMSO, ethanol | Slightly soluble in water; soluble in DMSO, chloroform | Slightly soluble in water; soluble in DMSO, ethanol, chloroform |
| Bioavailability | 30–50% (oral); rapid blood-brain barrier crossing | 60–80% (oral); high BBB penetration | 50–60% (oral); enhanced by fat intake | 60–80% (oral); efficient BBB crossing |
| Half-Life (Human) | 1–2 hours (short; effects persist via receptor binding) | 2–3 hours (short) | 1–2 hours (short) | 4–6 hours (longer than other racetams) |
| Common Side Effects | Rare at low doses: Headache (mitigated by choline), mild insomnia | Minimal: Headache, nausea (only at very high doses) | Mild: Headache, drowsiness, GI upset | Mild: Headache, nausea, irritability (dose-dependent) |
| Key Differentiator | Most targeted cholinergic modulator; lowest therapeutic dose | First racetam; safest profile (low side effect risk) | Only racetam with consistent anxiolytic effects | Longest half-life; best for sustained cognitive tasks |
| Regulatory Status | Research chemical (not approved for human use) | Dietary supplement (most regions); prescription in some EU countries | Dietary supplement (U.S.); research chemical (EU) | Dietary supplement (U.S.); research chemical (EU) |
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Yinherb Lab founded in 2009, has been deeply committed to the biotechnology field for over a decade. Today, it has established a professional development framework integrating "R&D + production" as an integrated system. And always adhered to the core business philosophy of "Quality First, Service Second, Price Third".
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